Publication

The COVID-19 epidemic is multifactorial but diet has not been sufficiently considered in severity. Geographic differences in COVID-19 mortality suggest the importance of diet. Clinical studies in three patients have contributed to developing a proof-of-concept for the hypothesis that combined Nrf2-TRPA1 foods may be beneficial for some COVID-19 symptoms.

1. 1. Rapid TRP (transient receptor potential) desensitization in COVID-19: fact or fancy?

A common denominator in all conditions associated with COVID-19 appears to be the oxidative stress storm. Antioxidant nutrients may be of importance in COVID-19 through Nrf2 activation. TRP (Transient Receptor Potential) desensitization has been suggested in 6 COVID-19 patients since broccoli capsules (potent Nrf2 and weak TRPA1 agonist) reduced cough and nasal obstruction within 10-20 minutes. A series of cough induced challenges were carried out in one COVI-19 patient. Curcuma and black pepper, ginger or green tea all improved cough and nasal obstruction in less than 2 minutes.

Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, Anna Bedbrook, Piotr Kuna, Josep M Anto

1. Oral capsaicin induces a very fast improvement in COVID-19 symptoms suggesting TRPV1 channel desensitization
2. TRPA1 and COVID 141020Potential control of COVID-19 symptoms by Nrf2-interacting nutrients with TRPA1 (transient receptor potential ankyrin 1) agonist activity

   Jean Bousquet, Wienczyslawa Czarlewski, Torsten Zuberbier, Joaquim Mullol, Hubert Blain, Raphael de la Torre Anna Bedbrook, Alessandro Fiocchi, Tari Haahtela, Ludger Klimek, Piotr Kuna, Nikolaos Papadopoulos, Aziz Sheikh, Arunas Valiulis, Josep M Anto

3. COVID-19: Why Germany’s case fatality rate seems so low
4. Covid-diet CTA
5. Association fermented foods
6. Cabbage and fermented vegetables: From death rate heterogeneity in
   countries to candidates for mitigation strategies of severe COVID‐19
7. Nrf2 nutrientsNrf2-TPRA1 interacting nutrients, insulin resistance and COVID-19: Time for research to develop mitigation strategies

   Jean Bousquet ^(1-3), Jean-Paul Cristol ⁽⁴⁾, Wienczyslawa Czarlewski ^(5-6), Josep M Anto ^(7-10), Adrian Martineau ⁽¹¹⁾, Tari Haahtela ⁽¹²⁾, Susana C Fonseca ⁽¹³⁾, Guido Iaccarino ⁽¹⁴⁾, Hubert Blain ⁽¹⁵⁾, Alessandro Fiocchi ⁽¹⁶⁾, G Walter Canonica ⁽¹⁷⁾, Joao A Fonseca ⁽¹⁸⁾, Alain Vidal ⁽¹⁹⁾, Hak-Jong Choi ⁽²⁰⁾, Hyun Ju Kim ⁽²¹⁾, Vincent Le Moing ⁽²²⁾, Jacques Reynes ⁽²²⁾, Aziz Sheikh ⁽²³⁾, Cezmi A Akdis ⁽²⁴⁾, Torsten Zuberbier⁽¹⁾, and the ARIA group

8. Clinical caseEfficacy of broccoli and glucoraphanin in COVID-19: From hypothesis to proof-of-concept with three experimental cases

   Jean Bousquet ^1-2, Vincent Le Moing ^3, Hubert Blain ⁴, Wienczyslawa Czarlewski ^5,6, Torsten Zuberbier ¹, Raphael de la Torre^8,9,10, Nieves Pizarro Lozano⁹, Jacques Reynes ³, Anna Bedbrook ^2,6, Jean-Paul Cristol ⁷, Alvaro A. Cruz¹³, Alessandro Fiocchi ¹⁴, Tari Haahtela ¹⁵, Guido Iaccarino¹⁶, Ludger Klimek ¹⁷, Piotr Kuna ¹⁸, Eric Melèn ¹⁹, Joaquim Mullol ²⁰, Boleslaw Samolinski ²¹, Arunas Valiulis ²², Josep M Anto ^9-12